GS-621763
GS-621763 is an orally available precursor to GS-441524 that exhibits anti-SARS-CoV-2 viral activity in mice. GS-621763 reduces viral load to undetectable levels in ferrets infected with SARS-CoV-2[1][2].
Product Specifications
CAS Number
2647442-13-3
UNSPSC
12352005
Target
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gs-621763.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C[C@]1(C2=CC=C3N2N=CN=C3N)[C@@H]([C@@H]([C@H](O1)COC(C(C)C)=O)OC(C(C)C)=O)OC(C(C)C)=O
Molecular Formula
C24H31N5O7
Molecular Weight
501.53
References & Citations
[1]Schäfer A, et al. Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice. bioRxiv [Preprint]. 2021 Sep 17:2021.09.13.460111.|[2]Cox RM, et al. Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets. Nat Commun. 2021 Nov 5;12 (1) :6415.|[3]Cox RM, et al. Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets. Nat Commun. 2021 Nov 5;12 (1) :6415.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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