Sevelamer (hydrochloride)

Sevelamer hydrochloride is an orally active and phosphate binding agent used for research of hyperphosphatemia with chronic kidney disease. Sevelamer hydrochloride consists of polyallylamine that is crosslinked with epichlorohydrin[1][2][3].

Product Specifications

CAS Number

[152751-57-0]

UNSPSC

12352211

Hazard Statement

H412

Target

Autophagy; FXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Sevelamer-hydrochloride.html

Purity

98.0

Solubility

DMSO : < 1 mg/mL

Smiles

NCC(CC(CC)CNCC(O)CNCC(C)CC(CC)CN)CC.[m].Cl.[m].[c].[b].[a]

Molecular Formula

(C3H7N.C3H5ClO) x.xHCl

Molecular Weight

186.08 (monomer)

Precautions

H412

References & Citations

[1]Sevelamer, From Wikipedia|[2]Bennis Y, et al. The Effect of Sevelamer on Serum Levels of Gut-Derived Uremic Toxins: Results from In Vitro Experiments and A Multicenter, Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Toxins (Basel) . 2019 May 17;11 (5) :279. |[3]Susan C Schiavi, et al. Npt2b deletion attenuates hyperphosphatemia associated with CKD. J Am Soc Nephrol. 2012 Oct;23 (10) :1691-700.