FR179642

FR179642 is a key intermediate in the synthesis of the echinocandin antifungal Micafungin[1]. FR179642 is the cyclic peptide nucleus of the echinocandin-like antifungal lipopeptide FR901379[2].

Product Specifications

CAS Number

[168110-44-9]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate

Type

Natural Products

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fr179642.html

Purity

99.84

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)[C@H](C(C=C3)=CC(O[S](=O)(O)=O)=C3O)O)=O)([H])[C@H](O)CC(N)=O)N(C[C@@H]4C)[C@@](C(N[C@@H]([C@@H](C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)N)O)O)=O)([H])[C@H]4O

Molecular Formula

C35H52N8O20S

Molecular Weight

936.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Satoshi Ueda, et al. Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907. J Antibiot (Tokyo) |[2]M Tomishima, et al. FK463, a novel water-soluble echinocandin lipopeptide: synthesis and antifungal activity. J Antibiot (Tokyo) |[3]Jiang X, et al., A Hadal Streptomyces-Derived Echinocandin Acylase Discovered through the Prioritization of Protein Families. Mar Drugs. 2024 May 7;22 (5) :212.