Rhodionin
Product Specifications
UNSPSC Description
Rhodionin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.761 μM and a Ki of 0.769 μM[1]. Rhodionin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL[2]. Rhodionin exhibits potent DPPH free radical scavenging activities, with an IC50 of 19.49 μM[3].
Target Antigen
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/rhodionin.html
Purity
98.78
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C1C(O)=C(C2=CC=C(O)C=C2)OC3=C(O)C(O[C@H]4[C@@H]([C@@H]([C@H]([C@H](C)O4)O)O)O)=CC(O)=C13
Molecular Weight
448.38
References & Citations
[1]Xu W, et al. Two potent cytochrome P450 2D6 inhibitors found in <i>Rhodiola rosea</i>. Pharmazie. 2013 Dec;68(12):974-6.|[2]Li FJ, et al. Molecular interaction studies of acetylcholinesterase with potential acetylcholinesterase inhibitors from the root of <i>Rhodiola crenulata</i> using molecular docking and isothermal titration calorimetry methods. Int J Biol Macromol. 2017 Nov;104(Pt A):527-532.|[3]Choe KI, et al. The antioxidant and anti-inflammatory effects of phenolic compounds isolated from the root of <i>Rhodiola sachalinensis</i> A. BOR. Molecules. 2012 Sep 27;17(10):11484-94.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0241/Rhodionin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0241/Rhodionin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
85571-15-9
Available Sizes
Curated Selection
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