Hexapeptide-11

Hexapeptide-11 is an anti-aging peptide that can protect fibroblasts from premature cell senescence mediated by oxidative stress. Hexapeptide-11 is also a potential stimulator of hyaluronic acid in keratinocytes, and can enhance skin barrier function by upregulating the expression of HAS2 and EGR3, and downregulating the expression of HYAL2. Hexapeptide-11 can also improve skin elasticity[1][2][3].

Product Specifications

CAS Number

[161258-30-6]

UNSPSC

12352209

Target

ATM/ATR; HSP; Keap1-Nrf2; MDM-2/p53; MMP; Reactive Oxygen Species (ROS)

Type

Peptides

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hexapeptide-11.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)[C@H]1N(C([C@H](CC2=CC=CC=C2)NC([C@H]3N(C([C@H](C)NC([C@H](C(C)C)NC([C@H](CC4=CC=CC=C4)N)=O)=O)=O)CCC3)=O)=O)CCC1

Molecular Formula

C36H48N6O7

Molecular Weight

676.80

References & Citations

[1]Errante F, et al. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020;8:572923.|[2]Sklirou AD, et al. Hexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblasts. Redox Biol. 2015 Aug;5:205-215.|[3]Widgerow AD, et al. Designing topical hyaluronic acid technology-Size does matter…. J Cosmet Dermatol. 2022 Jul;21 (7) :2865-2870.