Ziconotide

Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research[1].

Product Specifications

CAS Number

[107452-89-1]

Product Name Alternative

SNX-111

UNSPSC

12352209

Hazard Statement

H301+H331

Target

Calcium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/ziconotide.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@H](C(N[C@](CSSC[C@H](NC([C@@H](NC(CNC([C@@H](NC1=O)CO)=O)=O)CCCCN)=O)C(N)=O)([H])C(N[C@](CSSC[C@@H](C(N[C@H](C(NCC(N[C@H](C2=O)CCCCN)=O)=O)CCCCN)=O)N)([H])C(N[C@@](C(NCC(N[C@@]3([H])CO)=O)=O)([H])[C@H](O)C)=O)=O)=O)CC(O)=O)[C@](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@](CSSC[C@](C(N[C@@]1([H])CCCNC(N)=N)=O)([H])NC3=O)([H])NC([C@](NC([C@@H](NC(CN2)=O)C)=O)([H])CCCCN)=O)=O)CO)=O)CCCNC(N)=N)=O)CC(C)C)=O)CCSC)=O)([H])CC4=CC=C(O)C=C4

Molecular Formula

C102H172N36O32S7

Molecular Weight

2639.13

Precautions

P261-P264-P270-P271-P304+P340-P330-P403+P233-P405-P501

References & Citations

[1]Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3 (1) :69-85.|[2]Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55 (12) :9307-9327.