ML-180

ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist with an IC50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1; IC50>10 μM) . ML-180 has the potential for LRH-1-dependent cancers[1][2].

Product Specifications

CAS Number

[863588-32-3]

Product Name Alternative

SR1848

UNSPSC

12352005

Hazard Statement

H302

Target

Orphan Nuclear Receptor; Orphan Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ml-180.html

Purity

99.96

Solubility

DMSO : 8.75 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N(C2CCCCC2)C(C=C(N3CCN(C4=CC=CC(Cl)=C4)CC3)N1)=O

Molecular Formula

C20H25ClN4O2

Molecular Weight

388.89

Precautions

H302

References & Citations

[1]Busby S, et al. Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2) .|[2]Corzo CA, et al. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Mol Pharmacol. 2015 Feb;87 (2) :296-304.