AWD 12-281
AWD 12-281 is an orally active and highly selective phosphodiesterase 4 (PDE4) inhibitor (IC50 = 9.7 nM) . AWD 12-281 is used in the study of allergic dermatitis, asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis[1][2].
Product Specifications
CAS Number
257892-33-4
Product Name Alternative
GW 842470
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/awd-12-281.html
Smiles
O=C(C(C1=CN(CC2=CC=C(C=C2)F)C3=C1C=C(O)C=C3)=O)NC4=C(Cl)C=NC=C4Cl
Molecular Formula
C22H14Cl2FN3O3
Molecular Weight
458.27
References & Citations
[1]Wolfgang Bäumer, et al. AWD 12-281, a highly selective phosphodiesterase 4 inhibitor, is effective in the prevention and treatment of inflammatory reactions in a model of allergic dermatitis. J Pharm Pharmacol. 2003 Aug;55 (8) :1107-14.|[2]Regina Draheim, et al. Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N- (3,5-dichloro-pyrid-4-yl) -[1- (4-fluorobenzyl) -5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations. J Pharmacol Exp Ther. 2004 Feb;308 (2) :555-63.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE4
Available Sizes
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