Nurr1 agonist 9
Nurr1 agonist 9 (Compound 36) is an agonist for Nurr1 with an EC50 of 0.090 µM and a Kd of 0.17 µM. Nurr1 agonist 9 activates the Nurr1 homodimer (NurRE, EC50=0.094 µM) and the Nurr1-RXR heterodimer (DR5, EC50=0.165 µM) . Nurr1 agonist 9 induces the expression of Nurr1-regulated tyrosine hydroxylase (TH) in organoid Parkinson's Disease model. Nurr1 agonist 9 is human brain endothelial cell barrier prmeable[1].
Product Specifications
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nurr1-agonist-9.html
Smiles
CC1=C(NC(C2=CC=C(C3=CC=C(N(C)C)C=C3)O2)=O)N(C=CC=C4Cl)C4=N1
Molecular Formula
C21H19ClN4O2
Molecular Weight
394.85
References & Citations
[1]Sai M, et al., Development of Nurr1 agonists from amodiaquine by scaffold hopping and fragment growing. Commun Chem. 2024 Jun 29;7 (1) :149.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nurr1/NR4A2
Frequently Asked Questions
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