Ac-hMCH (6-16) -NH2

Ac-hMCH (6-16) -NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R[1].

Product Specifications

CAS Number

[353486-32-5]

UNSPSC

12352209

Target

MCHR1 (GPR24)

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ac-hmch-6-16-nh2.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC1=O)=O)CCCNC(N)=N)=O)C(C)C)=O)CC(C=C2)=CC=C2O)=O)CCCNC(N)=N)N3[C@@](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H]1CC(C)C)=O)CCSC)=O)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)C(N)=O)=O)([H])CCC3

Molecular Formula

C58H97N21O13S3

Molecular Weight

1392.72

References & Citations

[1]Maria A Bednarek, et al. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. J Biol Chem. 2002 Apr 19;277 (16) :13821-6.