Carbamazepine (Standard)

Carbamazepine (Standard) is the analytical standard of Carbamazepine. This product is intended for research and analytical applications. Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker with an IC50 of 131 μM. Carbamazepine blocks voltage gated Na+, Ca2+, and K+ channels, and is also a HDAC inhibitor (IC50: 2 μM) . Carbamazepine is an anticonvulsant and can be used for research of epilepsy and neuropathic pain[1][2][3].

Product Specifications

CAS Number

[298-46-4]

Product Name Alternative

CBZ (Standard) ; NSC 169864 (Standard)

UNSPSC

12352005

Hazard Statement

H302-H317-H336-H360

Target

Autophagy; Calcium Channel; HDAC; Mitophagy; Potassium Channel; Reference Standards; Sodium Channel

Type

Reference Standards

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Epigenetics; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/carbamazepine-standard.html

Purity

99.97

Smiles

O=C(N1C2=CC=CC=C2C=CC3=CC=CC=C31)N

Molecular Formula

C15H12N2O

Molecular Weight

236.27

Precautions

P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22 (3) : p. 627-35.|[2]Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28 (2) : p. 143-53.|[3]Beutler AS, et al. Carbamazepine is an inhibitor of histone deacetylases. Life Sci. 2005 May 13;76 (26) :3107-15.|[4]Turpin E, et al. Carbamazepine directly inhibits adipocyte differentiation through activation of the ERK 1/2 pathway. Br J Pharmacol. 2013 Jan;168 (1) :139-50.|[5]Wang CH, et al. Carbamazepine attenuates inducible nitric oxide synthase expression through Akt inhibition in activated microglial cells. Pharm Biol. 2014 Nov;52 (11) :1451-9. |[6]Kawaguchi T, et al. Carbamazepine promotes liver regeneration and survival in mice. J Hepatol. 2013 Dec;59 (6) :1239-45.|[7]Kara NZ, et al. Chronic oral carbamazepine treatment elicits mood-stabilising effects in mice. Acta Neuropsychiatr. 2014 Feb;26 (1) :29-34.