MTX115325

MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1].

Product Specifications

CAS Number

[2750895-97-5]

UNSPSC

12352005

Target

Deubiquitinase; Mitophagy

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mtx115325.html

Purity

99.91

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=NC=C(C2=CC=NC(C#N)=C2)O1)N3[C@]4([H])[C@@](CC3)([H])[C@H](N(C4)C#N)C

Molecular Formula

C18H16N6O2

Molecular Weight

348.36

References & Citations

[1]Fang TZ et al. Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model. Nat Commun. 2023 Nov 13;14 (1) :7295.