MTX115325
Product Specifications
UNSPSC Description
MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1].
Target Antigen
Deubiquitinase; Mitophagy
Type
Reference compound
Related Pathways
Autophagy;Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mtx115325.html
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=C(C2=CC=NC(C#N)=C2)O1)N3[C@]4([H])[C@@](CC3)([H])[C@H](N(C4)C#N)C
Molecular Weight
348.36
References & Citations
[1]Fang TZ et al. Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model. Nat Commun. 2023 Nov 13;14(1):7295.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-160019/MTX115325-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-160019/MTX115325-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2750895-97-5
Available Sizes
Curated Selection
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