Human PTH- (1-31)

Human PTH- (1-31) is the 1-31 fragment of human PTH. Human PTH- (1-31) stimulates the release of cAMP and also is a weaker stimulator of the 25-hydroxyvitamin D-1α-hydroxylase. Human PTH- (1-31) induces bone formation without inducing bone resorption. Human PTH- (1-31) has the potential for the research of osteoporosis[1][2].

Product Specifications

CAS Number

[157938-23-3]

UNSPSC

12352209

Target

Thyroid Hormone Receptor

Type

Peptides

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/human-pth-1-31.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(NCC(N[C@@H](CCCCN)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CO)N

Molecular Formula

C162H269N49O47S2

Molecular Weight

3719.30

References & Citations

[1]Fraher LJ, et al. Comparison of the biochemical responses to human parathyroid hormone- (1-31) NH2 and hPTH- (1-34) in healthy humans. J Clin Endocrinol Metab. 1999 Aug;84 (8) :2739-43.|[2]K. Henriksen, et al. Evaluation of the efficacy, safety and pharmacokinetic profile of oral recombinant human parathyroid hormone [rhPTH (1-31) NH2] in postmenopausal women with osteoporosis. Bone. 2013, 53 (1) : 160-166.