Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Brentuximab

Brentuximab is a monoclonal antibody targeting CD30. Brentuximab is conjugated with monomethyl auristatin E (MMAE) (HY-15162) to form the antibody-drug conjugate Brentuximab vedotin (HY-P99107), which can induce apoptosis in primary effusion lymphoma cells. Brentuximab vedotin exhibits antitumor activity with an IC50 of 10 nM against human CD30+ cancer cells[1][2][3].

Product Specifications

CAS Number

[2088770-90-3]

UNSPSC

12352203

Target

ADC Antibody; TNF Receptor

Type

Inhibitory Antibodies

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brentuximab.html

Purity

99.64

Solubility

10 mM in DMSO

Smiles

[Brentuximab]

Molecular Weight

(145.48 kDa)

References & Citations

[1]Bhatt S, et al. CD30 targeting with brentuximab vedotin: a novel therapeutic approach to primary effusion lymphoma. Blood. 2013 Aug 15;122 (7) :1233-42. |[2]Chen R W, et al. Inhibition of MDR1 overcomes brentuximab vedotin resistance in Hodgkin lymphoma cell line model and is synergistic with brentuximab vedotin in mouse xenograft model[J]. Blood, 2016, 128 (22) : 752.|[3]Wang Z, et al. CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model. FEBS Open Bio. 2023 Jul;13 (7) :1309-1319.

Shipping Conditions

Dry Ice

Storage Conditions

Store at -80°C for 2 years

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P99151/Brentuximab-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P99151/Brentuximab-SDS-MedChemExpress.pdf

Scientific Category

Inhibitory Antibodies

Clinical Information

Phase 4

Isoform

TNFRSF8/CD30

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)
MBS1111679-01 0.02 mg (E-Coli)

Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)

Ask
View Details
Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)
MBS1111679-02 0.1 mg (E-Coli)

Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)

Ask
View Details
Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)
MBS1111679-03 0.02 mg (Yeast)

Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)

Ask
View Details
Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)
MBS1111679-04 0.1 mg (Yeast)

Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)

Ask
View Details
Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)
MBS1111679-05 0.02 mg (Baculovirus)

Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)

Ask
View Details
Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)
MBS1111679-06 1 mg (E-Coli)

Recombinant Lactobacillus casei UPF0145 protein LCABL_07110 (LCABL_07110)

Ask
View Details