JAK1-IN-16

JAK1-IN-16 (compound 4l) is an inhibitor of JAK1/STAT3 and effectively downregulates TLR4 protein expression.[1].

Product Specifications

UNSPSC

12352005

Target

JAK; STAT; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jak1-in-16.html

Smiles

CC1=CC=C(C=C1)C2=NN=C(C=C2)SCC(NC3=CC=C(C(C(F)(F)F)=C3)Cl)=O

Molecular Formula

C20H15ClF3N3OS

Molecular Weight

437.87

References & Citations

[1]Shaldam MA, et al. Muti-target rationale design of novel substituted N-phenyl-2- ((6-phenylpyridazin-3-yl) thio) acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations. Bioorg Chem. 2024 Dec;153:107843.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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