JAK1-IN-16
JAK1-IN-16 (compound 4l) is an inhibitor of JAK1/STAT3 and effectively downregulates TLR4 protein expression.[1].
Product Specifications
UNSPSC
12352005
Target
JAK; STAT; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Epigenetics; Immunology/Inflammation; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak1-in-16.html
Smiles
CC1=CC=C(C=C1)C2=NN=C(C=C2)SCC(NC3=CC=C(C(C(F)(F)F)=C3)Cl)=O
Molecular Formula
C20H15ClF3N3OS
Molecular Weight
437.87
References & Citations
[1]Shaldam MA, et al. Muti-target rationale design of novel substituted N-phenyl-2- ((6-phenylpyridazin-3-yl) thio) acetamide candidates as telomerase/JAK1/STAT3/TLR4 inhibitors: In vitro and in vivo investigations. Bioorg Chem. 2024 Dec;153:107843.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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