Nitidine (chloride) (Standard)

Nitidine (chloride) (Standard) is the analytical standard of Nitidine (chloride) . This product is intended for research and analytical applications. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway[1][2][3][4][5][6].

Product Specifications

CAS Number

[13063-04-2]

UNSPSC

12352005

Target

Apoptosis; ERK; FAK; NF-κB; p38 MAPK; Parasite; Reference Standards; STAT; Topoisomerase

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; MAPK/ERK Pathway; NF-κB; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nitidine-chloride-standard.html

Smiles

C[N+]1=CC2=CC(OC)=C(OC)C=C2C(C=CC3=C4)=C1C3=CC5=C4OCO5.[Cl-]

Molecular Formula

C21H18ClNO4

Molecular Weight

383.82

References & Citations

[1]Chen J, et al. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11 (2) :277-87.|[2]Wang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144 (1) :145-50.|[3]Pan X, et al. Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway. Cancer Lett. 2011 Dec 27;313 (2) :181-91.|[4]Fang Z, et al. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Food Chem Toxicol. 2014 Apr;66:210-6.|[5]Liu LM, et al. DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride. Int J Oncol. 2018 Nov;53 (5) :1897-1912.|[6]Bouquet J, et al. Biological activities of nitidine, a potential anti-malarial lead compound. Malar J. 2012 Mar 9;11:67.