Cbz-B3A
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1) .
Product Specifications
CAS Number
1884710-81-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MTOR
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Cbz-B3A.html
Purity
98.63
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
O=C(OC(C)(C)C)N/C(NC(OC(C)(C)C)=O)=N/CCC[C@H](NC(OC(C)(C)C)=O)C(NCCCCCCNC(OCC1=CC=CC=C1)=O)=O
Molecular Formula
C35H58N6O9
Molecular Weight
706.87
Precautions
H302, H315, H319, H335
References & Citations
[1]Coffey RT, et al. Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. J Biol Chem. 2016 Mar 4;291 (10) :5221-33.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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