Cbz-B3A

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1) .

Product Specifications

CAS Number

[1884710-81-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MTOR

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Cbz-B3A.html

Purity

98.63

Solubility

DMSO : 20 mg/mL (ultrasonic; warming)

Smiles

O=C(OC(C)(C)C)N/C(NC(OC(C)(C)C)=O)=N/CCC[C@H](NC(OC(C)(C)C)=O)C(NCCCCCCNC(OCC1=CC=CC=C1)=O)=O

Molecular Formula

C35H58N6O9

Molecular Weight

706.87

Precautions

H302, H315, H319, H335

References & Citations

[1]Coffey RT, et al. Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. J Biol Chem. 2016 Mar 4;291 (10) :5221-33.