w-Conotoxin SVIB

w-Conotoxin SVIB is a peptide toxin, it can be isolated from Conus venoms. w-Conotoxin SVIB inhibits twitch response with an IC50 value of 37 nM. w-Conotoxin SVIB induces respiratory distress and it can be lethal to mice at a high concentration[1][2].

O=C([C@@H](N)CSSC[C@H](NC1=O)C(NC(C(NCC(NC2CO)=O)=O)CO)=O)N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CSSC[C@H](NC3=O)C(N)=O)=O)CC(O)=O)=O)CC4=CC=C(O)C=C4)=O)CO)=O)[C@@H](C)O)=O)CCCCN)=O)CCCNC(N)=N)=O)CSSC[C@H](NC2=O)C(NCC(N[C@H](C(N[C@H](C(NCC(N[C@H]3CCCCN)=O)=O)CO)=O)CCCNC(N)=N)=O)=O)=O)CO)=O)CCC(N)=O)=O)=O)CCCCN)=O)CC(C)C)=O)CCCCN

[1]Ramilo CA, et al. Novel alpha- and omega-conotoxins from Conus striatus venom. Biochemistry. 1992 Oct 20;31(41):9919-26. |[2]Hong SJ, et al. Inhibition of neuromuscular transmission in the myenteric plexus of guinea-pig ileum by omega-conotoxins GVIA, MVIIA, MVIIC and SVIB. Br J Pharmacol. 1996 Jun;118(3):797-803.