CAIMP

CAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual) . cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC50 of 6.4 μmol/L[1].

Product Specifications

CAS Number

[1507367-51-2]

Product Name Alternative

Cyclic Adenosine-Inosine Monophosphate

UNSPSC

12352005

Target

IFNAR; NF-κB

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/caimp.html

Smiles

O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])OP(O)(OC[C@]3([H])[C@@]([C@H]([C@H](N4C5=C(C(N=CN5)=O)N=C4)O3)O)([H])OP(O)(OC2)=O)=O)N6C7=NC=NC(N)=C7N=C6

Molecular Formula

C20H23N9O13P2

Molecular Weight

659.40

References & Citations

[1]Chunyong Ding, et al. Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway. Acta Pharm Sin B. 2020 Dec;10 (12) :2272-2298.