CAIMP
CAIMP (Cyclic Adenosine-Inosine Monophosphate) is an effective synthetic cyclic dinucleotide. cAIMP activates IRF and NF-κB in the THP1 human monocyte reporter cell line (THP1-Dual) . cAIMP induces the secretion of IFNs and pro-inflammatory cytokines in vitro in human blood, with an EC50 of 6.4 μmol/L[1].
Product Specifications
CAS Number
1507367-51-2
Product Name Alternative
Cyclic Adenosine-Inosine Monophosphate
UNSPSC
12352005
Target
IFNAR; NF-κB
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/caimp.html
Smiles
O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])OP(O)(OC[C@]3([H])[C@@]([C@H]([C@H](N4C5=C(C(N=CN5)=O)N=C4)O3)O)([H])OP(O)(OC2)=O)=O)N6C7=NC=NC(N)=C7N=C6
Molecular Formula
C20H23N9O13P2
Molecular Weight
659.40
References & Citations
[1]Chunyong Ding, et al. Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway. Acta Pharm Sin B. 2020 Dec;10 (12) :2272-2298.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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