SMN Tudor Domain Human Recombinant

<strong>SMN Tudor Domain Human Recombinant</strong>_x000D_ <strong>Catalog number:</strong> B2017245_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 37.9 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> Component of Gems 1, Gemin-1, Survival Motor Neuron Protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Locatelli D, d'Errico P, Capra S, Finardi A, Colciaghi F, Setola V, Terao M, Garattini E, Battaglia G. Spinal muscular atrophy pathogenic mutations impair the axonogenic properties of axonal-survival of motor neuron J Neurochem. 2012 May;121(3):465-74._x000D_ 2: Sabra M, Texier P, El Maalouf J, Lomonte P. The Tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated lysine 79 of histone H3 J Cell Sci. 2013 Aug 15;126(Pt 16):3664-77._x000D_ 3: Côté J, Richard S. Tudor domains bind symmetrical dimethylated arginines J Biol Chem. 2005 Aug 5;280(31):28476-83._x000D_ 4: Sun Y, Grimmler M, Schwarzer V, Schoenen F, Fischer U, Wirth B. Molecular and functional analysis of intragenic SMN1 mutations in patients with spinal muscular atrophy Hum Mutat. 2005 Jan;25(1):64-71._x000D_ 5: Brahms H, Meheus L, de Brabandere V, Fischer U, Lührmann R. Symmetrical dimethylation of arginine residues in spliceosomal Sm protein B/B' and the Sm-like protein LSm4, and their interaction with the SMN protein RNA. 2001 Nov;7(11):1531-42._x000D_ 6: Binda O, Kimenyi Ishimwe AB, Galloy M, Jacquet K, Corpet A, Fradet-Turcotte A, Côté J, Lomonte P. The TUDOR domain of SMN is an H3K79(me1) histone mark reader Life Sci Alliance. 2023 Mar 7;6(6):e202201752._x000D_ 7: Ying M, Chen D. Tudor domain-containing proteins of Drosophila melanogaster Dev Growth Differ. 2012 Jan;54(1):32-43._x000D_ 8: Selenko P, Sprangers R, Stier G, Bühler D, Fischer U, Sattler M. SMN tudor domain structure and its interaction with the Sm proteins Nat Struct Biol. 2001 Jan;8(1):27-31._x000D_ 9: Fortuna TR, Kour S, Chimata AV, Muiños-Bühl A, Anderson EN, Nelson Iv CH, Ward C, Chauhan O, O'Brien C, Rajasundaram D, Rajan DS, Wirth B, Singh A, Pandey UB. SMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration Acta Neuropathol. 2023 Sep;146(3):477-498._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/36114190">10: Liu Y, Iqbal A, Li W, Ni Z, Wang Y, Ramprasad J, Abraham KJ, Zhang M, Zhao DY, Qin S, Loppnau P, Jiang H, Guo X, Brown PJ, Zhen X, Xu G, Mekhail K, Ji X, Bedford MT, Greenblatt JF, Min J. A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II Nat Commun. 2022 Sep 16;13(1):5453. </a>_x000D_ _x000D_ <strong>Products Related to SMN Tudor Domain Human Recombinant can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>