RAGE antagonist peptide (TFA)
RAGE antagonist peptide TFA is an advanced glycation end products (RAGE) antagonist. RAGE antagonist peptide TFA prevents RAGE from binding with several of its most important ligands, including HMGB-1, S100P, and S100A4. RAGE antagonist peptide TFA possesses anti-tumor and anti-inflammatory activities[1][2].
Product Specifications
UNSPSC
12352209
Target
Amyloid-β
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rage-antagonist-peptide-tfa.html
Purity
99.41
Solubility
DMSO : ≥ 50 mg/mL|H2O : 14.29 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCSC)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)NC(C)=O.O=C(O)C(F)(F)F
Molecular Formula
C59H102F3N13O19S
Molecular Weight
1386.58
References & Citations
[1]Thiruvengadam Arumugam, et al. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis. Clin Cancer Res. 2012 Aug 15;18 (16) :4356-64.|[2]Lihong Yao, et al. The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model. Br J Pharmacol. 2016 Sep;173 (17) :2600-13.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Int J Biol Sci. 2024 Jan 1;20 (2) :784-800.|Adv Biol (Weinh) . 2025 Jun 4:e00761.|Cell Commun Signal. 2023 May 1;21 (1) :86.|J Immunol. 2025 Jun 28:vkaf125.
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