Pridopidine

Pridopidine is a phenylpiperidine dopaminergic stabilizer. It is a low affinity dopamine D2 receptor antagonist and a potent sigma-1 receptor (S1R) agonist. The affinity of pridopidine for S1R is 100-fold higher than the affinity for D2 Receptor (high-affinity Ki of 70 nM at S1R and 7520 nM at D2 receptor). It improves motor function and shows neuroprotective effects in Huntington Disease mouse model. Due to interaction of the SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors, modulators of sigma receptors are being investigated for the treatment of SARS-Cov-2.