Meglumine

Meglumine is a derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. It is used as an excipient for drug formulations and for preparing salts. The meglumine or combined meglumine-sodium salts of triiodinated benzoic acid derivatives, diatrizoic and iothalamic acid, are commonly used as intravascular ionic contrast media for radiographic visualization of blood vessels and the urinary tract. Meglumine salts of iodoxamate and iodipamide are also used for intravenous cholangiography. Meglumine shows protective effects in Type II Diabetes. It significantly improves glycemic control and lowers levels of plasma and liver triglycerides in a mice model of type 2 Diabetes.