Bisantrene dihydrochloride

Bisantrene dihydrochloride is the hydrochloride salt of an anthracenyl bishydrazone with antineoplastic activity. It intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin (Cat. No. 1527) in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance