Aramchol

Aramchol is a conjugate of cholic acid and arachidic acid. It is a synthetic fatty-acid/bile-acid conjugate (FABAC). It significantly reduces hepatic fat content in a high fat diet animal model. It dissolves pre-existing cholesterol crystals in model bile solutions. It causes 70% to 83% inhibition of stearoyl coenzyme A desaturase 1 (SCD1) activity in vitro. Aramchol (0.5 mg or 1.0 mg/d) reduces the development of gallstones or cholesterol crystals in mice fed a lithogenic high-fat diet. It significantly reduces liver fat content in patients with nonalcoholic fatty liver disease.