AM-251

AM251 is a selective cannabinoid 1 (CB1) receptor antagonist with an IC50 of 8 nM. It also acts as an agonist at GPR55 (EC50 = 39 nM) and potentiates GABAA receptor currents (EC50 = 0.4 µM). In mice, AM251 reduces antidepressant-like behavior in the tail suspension and forced swim tests and decreases hyperphagia induced by fasting.