Ro 08-2750

Ro 08-2750 is an antagonist of nerve growth factor (NGF). It binds to the NGF dimer (Kd ~ 1 μM) and probably induces a change in its conformation such that NGF cannot bind to neurotrophin receptor p75(NTR). It inhibits NGF-induced cell death of SK-N-MC cells. It reverses NGF-induced decrease in β-catenin mRNA expression and decrease in migration of SKOV3 and OVCAR-3 ovarian cancer cells at a concentration 10 μM.