Pemafibrate, Free Acid

Pemafibrate free acid (K877) is a selective peroxisome proliferator-activated receptor-α (PPAR-α) modulator and a next-generation PPAR-α agonist. It activated PPAR-α, PPAR-γ, and PPAR-δ with EC₅₀ values of 1 nM, 2.3 µM, and 1 µM, respectively.