TCS 5861528

TCS 5861528 is a selective transient receptor potential ankyrin 1 (TRPA1) blocker that antagonizes TRPA1-mediated calcium influx induced by allyl isothiocyanate and 4-hydroxy nonenal with IC₅₀ values of 14.3 and 18.7 μM, respectively. Chronic administration of TCS 5861528 (30 mg/kg twice daily) in diabetic rats attenuates pain-related behavior and development of mechanical hypersensitivity.