NSC-617145

NSC- 617145 is an inhibitor of Werner syndrome helicase (WRN) (IC₅₀ = 250 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only displaying 7% inhibition of RECQ1 at a concentration of 5 µM. It acts synergistically with Mitomycin C (Cat. No. 2713) to induce double-strand breaks and chromosomal abnormalities in vitro.