ONC212

ONC212 is a fluorinated imipridone analogue of ONC201. It is an activator of GPCR GPR132 and Gαq signaling, which functions as a tumor suppressor. It induces apoptosis in HPAF-II and AsPC1 cell lines at 20 μM and potently prevents colony formation at 5 μM in HPAF-II cells. It inhibits acute myeloid leukemia growth in vivo and improves overall survival in xenografted mice.