DSM265

DSM265 is a potent, selective and long duration dihydroorotate dehydrogenase (DHODH)) inhibitor (IC₅₀ = 8.9 nM). DSM265 is potential useful for the prevention and treatment of malaria. DSM265 is highly selective towards DHODH of the malaria parasite Plasmodium, efficacious against both blood and liver stages of P. falciparum, and active against drug-resistant parasite isolates.