NMS-1286937

NMS-1286937 a potent, small-molecule Polo-like kinase 1 (PLK1) inhibitor (IC₅₀ = 2 nM) with potential antineoplastic activity. It selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells.