AM-8123

AM-8123 is an orally active and potent APJ agonist. AM-8123 inhibits Forskolin-stimulated cAMP production and promotes Gα protein activation. AM-8123 can be used for the research of cardiovascular disease[1].

Product Specifications

CAS Number

[2049973-02-4]

UNSPSC

12352005

Target

Apelin Receptor (APJ)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/am-8123.html

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)O[C@@H](C1=NC=C(C)C=N1)[C@H](C)S(NC2=NN=C(C3=CN=CC(C)=C3)N2C4=C(C=CC=C4OC)OC)(=O)=O

Molecular Formula

C27H33N7O5S

Molecular Weight

567.66

References & Citations

[1]Ason B, et al. Cardiovascular response to small-molecule APJ activation. JCI Insight. 2020;5 (8) :e132898. Published 2020 Apr 23. doi:10.1172/jci.insight.132898