Taxifolin-d3

Taxifolin-d3 is deuterium labeled Taxifolin. Taxifolin ((+) -Dihydroquercetin) exhibits important anti-tyrosinase activity. Taxifolin exhibits significant inhibitory activity against collagenase with an IC50 value of 193.3 μM[1]. Taxifolin is an important natural compound with antifibrotic activity. Taxifolin is a free radical scavenger with antioxidant capacity[2].

Product Specifications

Product Name Alternative

(+) -Dihydroquercetin-d3; (+) -Taxifolin-d3

UNSPSC

12352005

Target

Autophagy; Isotope-Labeled Compounds; Tyrosinase

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

O=C1[C@H](O)[C@@H](C2=C([2H])C([2H])=C(O)C(O)=C2[2H])OC3=CC(O)=CC(O)=C13

Molecular Formula

C15H9D3O7

Molecular Weight

307.27

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21 (11) :1586.|[3]Lei Ren, et al. Dissecting Efficacy and Metabolic Characteristic Mechanism of Taxifolin on Renal Fibrosis by Multivariate Approach and Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometry-Based Metabolomics Strategy. Front Pharmacol. 2021 Jan 14;11:608511.|[4]Yang P, et al. Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MS (n) . Molecules. 2016 Sep 13;21 (9) . pii: E1209.