Human Integrin alpha 9 beta 1 (ITGA9&ITGB1) Heterodimer Protein, His Tag&Tag Free

Integrin alpha 9 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 (CD29) subunit. It is the non-covalent heterodimer of 150 kDa alpha 9 and 130 kDa beta 1 type I transmembrane glycoprotein subunits. The integrin alpha 9 beta 1 mediates cell adhesion to tenascin-C and VCAM-1 by binding to sequences distinct from the common integrin-recognition sequence, arginine-glycine-aspartic acid (RGD) . A thrombin-cleaved NH (2) -terminal fragment of osteopontin containing the RGD sequence has recently been shown to also be a ligand for integrin alpha 9 beta 1.

Product Specifications

Background

Specifications

Human ITGA9&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA9 and ITGB1, has a calculated MW of 111.1 kDa (ITGA9) and 82.7 kDa (ITGB1) . Subunit ITGA9 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The reducing (NR) protein migrates as 210-240 kDa respectively due to glycosylation.

Accession Number

Q13797-1 (ITGA9) & P05556-1 (ITGB1)

Expression Region

Tyr 30 - Trp 981 (ITGA9) & Gln 21 - Asp 728 (ITGB1)

Host

HEK293

Target

Integrin alpha 9 beta 1

Conjugation

Unconjugated

Tag

C-10xHis | Native

Source

Human

Stability

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.