Gut restricted-7
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice[1].
Product Specifications
CAS Number
2553218-46-3
Product Name Alternative
GR-7
UNSPSC
12352100
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/gut-restricted-7.html
Purity
98.62
Solubility
DMSO : 233.33 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C(CF)CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Molecular Formula
C25H40FNaO6S
Molecular Weight
510.63
References & Citations
[1]Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 Mar;16 (3) :318-326.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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