α-Muricholic acid-d4

α-Muricholic acid-d4 is the deuterium labeled α-Muricholic acid. α-Muricholic acid is the most abundant primary bile acid in rodents[1][2].

Product Specifications

Product Name Alternative

MK-0364

UNSPSC

12352211

Target

Endogenous Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Endocrinology

Solubility

10 mM in DMSO

Smiles

C[C@@H]([C@]1(CC[C@]2([C@@]3([C@@H]([C@H]([C@@]4(C([2H])([C@@H](C([2H])(C[C@@]4([C@]3(CC[C@@]21C)[H])C)[2H])O)[2H])[H])O)O)[H])[H])[H])CCC(O)=O

Molecular Formula

C24H36D4O5

Molecular Weight

412.60

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Eyssen HJ, et al. Sulfate bile acids in germ-free and conventional mice. Eur J Biochem. 1976 Jul 15;66 (3) :507-14.|[3]Watanabe K, et al. Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids. PLoS One. 2018 Aug 13;13 (8) :e0202083.