Sulfapyridine (Standard)

Sulfapyridine (Standard) is the analytical standard of Sulfapyridine. This product is intended for research and analytical applications. Sulfapyridine, a major metabolite of Sulfasalazine, is a sulfonamide antibiotic agent. Sulfapyridine inhibits recombinant P. carinii dihydropteroate synthetase (DHPS) with an IC50 of 0.18 μM. Sulfapyridine has antibacterial, anti-inflammatory and anti-rheumatic activities[1][2][3].

Product Specifications

CAS Number

[144-83-2]

UNSPSC

12352005

Hazard Statement

H361

Target

Antibiotic; Bacterial; Reference Standards

Type

Reference Standards

Related Pathways

Anti-infection; Others

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sulfapyridine-standard.html

Purity

99.86

Solubility

H2O : < 0.1 mg/mL

Smiles

O=S(C1=CC=C(N)C=C1)(NC2=NC=CC=C2)=O

Molecular Formula

C11H11N3O2S

Molecular Weight

249.29

Precautions

H361

References & Citations

[1]Kazuki Omoteyama, et al. Effects of salazosulfapyridine on the profile of cell surface proteins, revealed by biotinylation of cell surface proteins and 2-dimentional electrophoresis. Biochim Biophys Acta Proteins Proteom. 2019 Jan;1867 (1) :47-56.|[2]J J Andreasen, et al. In vitro susceptibility of diarrhoea producing gram negative enteric bacteria to sulfasalazine, 5-aminosalicylic acid, sulfapyridine and four quinolones. Brief report. APMIS. 1988 Jun;96 (6) :568-70.|[3]Y L Hong, et al. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39 (8) :1756-63.|[4]H M Kim, et al. Inhibitory effect of mast cell-mediated immediate-type allergic reactions by sulfapyridine. Immunopharmacol Immunotoxicol. 2000 May;22 (2) :253-66.