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Sulfosuccinimidyl oleate

Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells. Sulfosuccinimidyl oleate is a potent and irreversible inhibitor of mitochondrial respiratory chain. Sulfosuccinimidyl oleate binds the CD36 receptor on the surface of microglia. Anti-inflammatory effect[1][2].

Product Specifications

CAS Number

[135661-44-8]

Product Name Alternative

Sulfo-N-succinimidyl oleate

UNSPSC

12352005

Hazard Statement

H315-H317-H319

Target

Mitophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Sulfosuccinimidyl_oleate.html

Solubility

10 mM in DMSO

Smiles

O=S(C(C1)C(N(OC(CCCCCCC/C=C\CCCCCCCC)=O)C1=O)=O)(O)=O

Molecular Formula

C22H37NO7S

Molecular Weight

459.60

Precautions

P261-P264-P272-P280-P302+P352-P305+P351+P338-P362+P364-P501

References & Citations

[1]Dhungana H, et al. Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation. J Neuroinflammation. 2017 Dec 4;14 (1) :237.|[2]Drahota Z, et al. Succinimidyl oleate, established inhibitor of CD36/FAT translocase inhibits complex III of mitochondrial respiratory chain. Biochem Biophys Res Commun. 2010 Jan 15;391 (3) :1348-51.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

BMC Cancer. 2023 Apr 21;23 (1) :367.|Cancer Lett. 2024 Jan 28:581:216511.|Cell Death Dis. 2025 Apr 14;16 (1) :291.|Cell Immunol. 2022 Feb:372:104475.|Cell Rep. 2024 Jul 9;43 (7) :114465.|CNS Neurosci Ther. 2023 Jun;29 Suppl 1 (Suppl 1) :161-184.|Food Res Int. 2023 Nov;173 (Pt 1) :113328.|Food Sci Nutr. 2023 Nov 22;12 (2) :1318-1329.|Front Pharmacol. 2020 Dec 16:11:593832.|Int J Biol Macromol. 2023 Dec 31;253 (Pt 8) :127324.|Int J Mol Sci. 2023 Aug 31;24 (17) :13516.|SSRN. 2023 Aug 30.|Toxicol Sci. 2023 Feb 17;191 (2) :276-284.|Toxins. 2021 Nov 13;13 (11) :802.|Cancer Cell Int. 2025 May 14;25 (1) :176.|Cancer Metab. 2025 Feb 7;13 (1) :6.|Cancer Res. 2025 Apr 28:OF1-OF13.|Cell Death Dis. 2024 Aug 26;15 (8) :623.|Cell Rep Med. 2024 May 29:101592.|Cell Rep. 2024 Oct 19;43 (11) :114881.|Fish Physiol Biochem. 2025 Nov 24;51 (6) :197.|Heliyon. 2024 Nov 28;10 (23) :e40806.|Int Immunopharmacol. 2025 Oct 15:167:115594.|Int J Mol Sci. 2025 Apr 8;26 (8) :3482.|J Agric Food Chem. 2024 Jul 24;72 (29) :16287-16297.|J Exp Med. 2023 Mar 6;220 (3) :e20221316.|J Invest Dermatol. 2025 Nov 20:S0022-202X (25) 03555-9.|J Transl Med. 2023 Feb 6;21 (1) :89.|JCI Insight. 2025 Feb 18;10 (6) :e184935.|Nutrients. 2025 Feb 25;17 (5) :794.|Redox Biol. 2025 Feb 3:80:103528.|Research Square Preprint. 2023 Oct 11.|Research Square Print. December 29th, 2022.|SSRN. 2025 Oct 22.|University of Chicago. 2025 Aug.

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