Verapamil EP Impurity C (hydrochloride)

NSC-609249 hydrochloride is an impurity of Verapamil (HY-14275) . Verapamil is a calcium channel blocker and a potent and orally active first-generation P-glycoprotein (P-gp) inhibitor[1][2].

Product Specifications

CAS Number

[51012-67-0]

Product Name Alternative

NSC-609249 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Calcium Channel; Cytochrome P450; P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/verapamil-ep-impurity-c-hydrochloride.html

Purity

99.61

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN(C)CCC1=CC=C(OC)C(OC)=C1.[H]Cl

Molecular Formula

C12H20ClNO2

Molecular Weight

245.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Gowarty JL, et al. Verapamil as a culprit of palbociclib toxicity. J Oncol Pharm Pract. 2019 Apr;25 (3) :743-746.|[2]Krikler DM. Verapamil in arrhythmia. Br J Clin Pharmacol. 1986;21 Suppl 2:183S-189S.