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N-DBCO-N-bis (PEG2-C2-acid)

N-DBCO-N-bis (PEG2-C2-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-DBCO-N-bis (PEG2-C2-acid) is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[2110449-00-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-dbco-n-bis-peg2-c2-acid.html

Purity

96.65

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N(CCOCCOCCC(O)=O)CCOCCOCCC(O)=O)=O

Molecular Formula

C33H40N2O10

Molecular Weight

624.68

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Available Sizes

Curated Selection

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