Jasplakinolide

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2].

Product Specifications

CAS Number

[102396-24-7]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Arp2/3 Complex; Fungal

Type

Natural Products

Related Pathways

Anti-infection; Cytoskeleton

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/jasplakinolide.html

Purity

99.56

Solubility

DMSO : ≥ 2mg/mL

Smiles

BrC1=C(C2=CC=CC=C2N1)C[C@@H](N(C([C@@H](NC([C@H](C/C(C)=C/[C@@H]3C)C)=O)C)=O)C)C(N[C@](C(C=C4)=CC=C4O)([H])CC(O[C@H](C3)C)=O)=O

Molecular Formula

C36H45BrN4O6

Molecular Weight

709.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Bubb MR, et al. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem. 1994 May 27;269 (21) :14869-71.|[2]Holzinger A, et al. Jasplakinolide: an actin-specific reagent that promotes actin polymerization. Methods Mol Biol. 2009;586:71-87.