Hamaudol
Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX) -1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].
Product Specifications
CAS Number
735-46-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
COX
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hamaudol.html
Purity
99.98
Solubility
DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=C2C(OC(C)(C)[C@@H](O)C2)=CC3=C1C(C=C(C)O3)=O
Molecular Formula
C15H16O5
Molecular Weight
276.28
Precautions
H302, H315, H319
References & Citations
[1]Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata) . Chem Pharm Bull (Tokyo) . 2001 Feb;49 (2) :154-60.|[2]Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13 (2) .
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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