Hamaudol

Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX) -1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].

Product Specifications

CAS Number

[735-46-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

COX

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hamaudol.html

Purity

99.98

Solubility

DMSO : 6.25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C2C(OC(C)(C)[C@@H](O)C2)=CC3=C1C(C=C(C)O3)=O

Molecular Formula

C15H16O5

Molecular Weight

276.28

Precautions

H302, H315, H319

References & Citations

[1]Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata) . Chem Pharm Bull (Tokyo) . 2001 Feb;49 (2) :154-60.|[2]Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13 (2) .