Hirsutenone
Hirsutenone is an active botanical diarylheptanoid present in Alnus species and exhibits many biological activities, including anti-inflammatory, anti-tumor promoting and anti-atopic dermatitis effects. Hirsutenone attenuates adipogenesis by binding directly to PI3K and ERK1 in a non-ATP competitive manner. Hirsutenone can be used for the study of obesity[1].
Product Specifications
CAS Number
[41137-87-5]
UNSPSC
12352005
Hazard Statement
H410
Target
ERK; PI3K
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hirsutenone.html
Purity
99.74
Solubility
10 mM in DMSO
Smiles
OC1=C(O)C=CC(CC/C=C/C(CCC2=CC(O)=C(O)C=C2)=O)=C1
Molecular Formula
C19H20O5
Molecular Weight
328.36
Precautions
H410
References & Citations
[1]Lai Yee Cheong, et al. Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3-L1 Preadipocytes.J Cell Biochem
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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