FGFR2 degrader 1
FGFR2 degrader 1 (compound 28E) is a selectively PROTACS degrader of FGFR2, with the DC50 of 0.645 nM. FGFR2 plays an important role in cancer research (Pink: ligand of target protein; black: linker; blue: ligand of E3 ligase).
Product Specifications
UNSPSC
12352005
Target
FGFR; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr2-degrader-1.html
Smiles
O=C1N(C2C(NC(CC2)=O)=O)C(C3=CC(NCCCCCC(NCCN4N=CC(/C=C/C5=NNC6=CC=C(O[C@H](C)C7=C(Cl)C=NC=C7Cl)C=C56)=C4)=O)=CC=C31)=O
Molecular Formula
C40H39Cl2N9O6
Molecular Weight
812.70
References & Citations
[1]Zuli Hu, et al. Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor. Eur J Med Chem. 2024 Sep 5:275:116612.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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