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Anti-Mouse CD132 (common γ chain) Antibody (3E12)

Anti-Mouse CD132 (common γ chain) Antibody (3E12) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse CD132. Anti-Mouse CD132 (common γ chain) Antibody (3E12) can block IL-2, IL-4 and IL-7. Anti-Mouse CD132 (common γ chain) Antibody (3E12) can inhibit T cells and B cells. Anti-Mouse CD132 (common γ chain) Antibody (3E12) can be used for the researches of cancer, immunology, inflammation and metabolic disease, such as tumor, skin transfer and diabetes[1][2][3][4].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

Interleukin Related

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-mouse-cd132-common-γ-chain-antibody-3e12.html

Solubility

10 mM in DMSO

Smiles

[Anti-MouseCD132(commonγchain)Antibody(3E12)]

Molecular Weight

(150 kDa)

References & Citations

[1]Malek TR, et al. Monoclonal antibodies to the common gamma-chain as cytokine receptor antagonists in vivo: effect on intrathymic and intestinal intraepithelial T lymphocyte development. J Leukoc Biol. 1998 Jun;63 (6) :643-9.|[2]Li, Jingyue and Liang, et al. Monocyte-Derived Interleukin-15 Mediates the Pro-Inflammatory Phenotype of Cd226+ B Cells in Type 1 Diabetes. |[3]Chang S, et al. Anti-gamma chain and anti-IL-2Rbeta mAbs in combination with donor splenocyte transfusion induce H-Y skin graft acceptance in murine model. Transplant Proc. 2009 Nov;41 (9) :3913-5.|[4]Lacher SB, et al. PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells. Nature. 2024 May;629 (8011) :417-425.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Frequently Asked Questions

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