FR139317
Product Specifications
UNSPSC Description
FR139317 (PD 147953) is a selective ETA receptor antagonist. FR139317 inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. FR139317 also ameliorates cerebral vasospasm in dogs[1][2].
Target Antigen
Endothelin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fr139317.html
Smiles
O=C(O)[C@@H](CC1=NC=CC=C1)NC([C@@H](CC2=CN(C)C3=CC=CC=C23)NC([C@H](CC(C)C)NC(N4CCCCCC4)=O)=O)=O
Molecular Weight
604.74
References & Citations
[1]Gross PM, et al. FR139317, a specific ETA-receptor antagonist, inhibits cerebral activation by intraventricular endothelin-1 in conscious rats. Neuropharmacology. 1994 Oct;33(10):1155-66. |[2]Nirei H, et al. An endothelin ETA receptor antagonist, FR139317, ameliorates cerebral vasospasm in dogs. Life Sci. 1993;52(23):1869-74.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-102092/FR139317-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-102092/
Clinical Information
Phase 2
CAS Number
142375-60-8
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
NBP2-73913AF750 0.1 mL
Mouse Monoclonal RIPPLY2 Antibody (OTI1B5) [Alexa Fluor 750]
Ask
View Details 
MBS6303765-01 0.2 mL
GPR15, CT (GPR15, G-protein coupled receptor 15, Brother of Bonzo) (PE)
Ask
View Details MBS6303765-02 5x 0.2 mL
GPR15, CT (GPR15, G-protein coupled receptor 15, Brother of Bonzo) (PE)
Ask
View Details